MucoSave™ FG - Clinical Research Data Summary

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MucoSave™ FG Prickly Pear & Olive Leaf Blend

MucoSave™ FG is a clinically studied ingredient used in the following Silver Fern™ Brand products:

Introduction

MucoSave™ FG is a clinically studied blend of Opuntia ficus-indica (prickly pear) polysaccharides and Olea europaea (olive leaf) polyphenols designed to support the natural protective lining of the upper digestive tract and promote digestive comfort. The ingredient combines plant-derived polysaccharides known for their soothing, mucoadhesive properties with antioxidant olive polyphenols that help support the integrity of gastrointestinal tissues. Together, these compounds help form a protective barrier along the upper digestive tract, supporting healthy digestive function and comfort following meals.*

These are the studies for MucoSave™ FG. Below, we provided a summary of each key data for each study, along with a link to the complete clinical research.

  1. Summary of Study 1 – Full Study: https://pubmed.ncbi.nlm.nih.gov/27818697/
  2. Summary of Study 2 – Full Study: https://clinicaltrials.gov/study/NCT04119817

Ingredient Manufacturer Link: https://bionap.com/products/mucosave-fg



Study 1 Summary

Complete Study Information: https://pubmed.ncbi.nlm.nih.gov/27818697/

Efficacy and Safety of a Natural Remedy for the Treatment of Gastroesophageal Reflux: A Double-Blinded Randomized-Controlled Study
Evid Based Complement Alternat Med. 2016;2016:2581461. doi: 10.1155/2016/2581461. Epub 2016 Oct 12. PMID: 27818697; PMCID: PMC5080480.

A randomized, double-blind, placebo-controlled clinical study evaluated the effectiveness of a formulation containing sodium alginate and bicarbonate combined with MucoSave™ FG, a standardized blend of Opuntia ficus-indica (prickly pear) polysaccharides and Olea europaea (olive leaf) polyphenols. In this study, 118 adults experiencing frequent digestive discomfort associated with gastric reflux episodes took either the active formulation or placebo daily for eight weeks. Participants taking the MucoSave™ FG formulation experienced significant improvements in digestive comfort and quality-of-life measures compared with placebo, including reductions in the frequency and intensity of upper digestive symptoms. The formulation was well tolerated and demonstrated meaningful support for upper gastrointestinal comfort.

Study Design Highlights

  • Study design: Randomized, double-blind, placebo-controlled clinical trial
  • Participants: 118 adults with frequent upper digestive discomfort
  • Duration: 8 weeks
  • Dose: 6 g/day of a formulation containing sodium alginate, sodium bicarbonate, and MucoSave™ FG

Key Findings (What the Study Showed)

Compared with placebo, the MucoSave™ FG formulation produced significant improvements in symptom and quality-of-life measures:

  • Digestive symptom score improvement: 59.1% reduction
  • Quality-of-life improvement related to digestive comfort: 56.5% improvement
  • Frequency of upper digestive discomfort episodes: significantly reduced
  • Intensity of digestive discomfort: significantly reduced
  • The formulation was reported to be safe and well tolerated

Benefits of MucoSave™ FG Demonstrated by This Study

Based directly on the clinical outcomes, MucoSave™ FG was shown to:
✓ Support a 59.1% reduction in digestive symptom scores
✓ Support a 56.5% improvement in digestive quality-of-life scores
✓ Significantly reduce the frequency of upper digestive discomfort episodes
✓ Significantly reduce the intensity of digestive discomfort
✓ Demonstrate a strong safety profile throughout the 8-week study period

Why This Study Matters

Daily supplementation with a MucoSave™ FG-containing formulation for eight weeks significantly improved digestive comfort and quality-of-life measures in adults experiencing frequent upper digestive discomfort. The results suggest that the formulation supports healthy upper gastrointestinal function and may help promote comfort following meals.*

Reference Link: https://pubmed.ncbi.nlm.nih.gov/27818697/



Study 2 Summary

Complete Study Information: https://clinicaltrials.gov/study/NCT04119817

Randomized, Double-Blind, Placebo-Controlled Trial Evaluating the Effects of MucoSave™ FG on Digestive Comfort in Healthy Adults
Malfa GA et al. Journal of Clinical Medicine. 2021.

Researchers conducted a randomized, double-blind, placebo-controlled clinical trial to evaluate the effects of MucoSave™ FG, a standardized blend of Opuntia ficus-indica (prickly pear) polysaccharides and Olea europaea (olive leaf) polyphenols, on digestive comfort and quality of life. In this study, 100 healthy adults experiencing gastrointestinal discomfort took either 400 mg of MucoSave™ FG or a placebo daily for eight weeks.

Study Design Highlights

  • Study design: Randomized, double-blind, placebo-controlled clinical trial
  • Participants: 100 healthy adults with gastrointestinal discomfort
  • Groups: 60 participants received MucoSave™ FG (400 mg/day); 40 participants received placebo
  • Duration: 8 weeks
  • Assessment tools: Gastrointestinal Quality of Life Index (GIQLI) and Gastroesophageal Symptom Assessment Scale (GSAS)
  • Assessment points: Baseline (T0), 4 weeks (T4), 8 weeks (T8)

Key Findings (What the Study Showed)

Digestive Symptom Improvements (compared with baseline)

  • Heartburn symptoms: reduced from 58% of participants to ~11.7%
  • Throat burning: reduced from 41.6% to 0–1.7%
  • Nausea: reduced from 48.3% to ~8–10%
  • Bloating: reduced from 86.7% to ~16–18%
  • Flatulence: reduced from 68.3% to ~10–12%

Time to Improvement

  • Noticeable improvements observed by 4 weeks
  • Continued benefits through 8 weeks

Overall Digestive Scores

Both GIQLI (digestive quality of life) and GSAS (digestive symptom severity) improved significantly in the MucoSave™ FG group compared with placebo.

Benefits of MucoSave™ FG Demonstrated by This Study

Based directly on the clinical outcomes, MucoSave™ FG at 400 mg/day was shown to:
✓ Support heartburn reduction from 58% to ~11.7% of participants
✓ Support throat burning reduction from 41.6% to 0–1.7% of participants
✓ Support nausea reduction from 48.3% to ~8–10% of participants
✓ Support bloating reduction from 86.7% to ~16–18% of participants
✓ Support flatulence reduction from 68.3% to ~10–12% of participants
✓ Produce measurable improvements in GIQLI and GSAS quality-of-life scores vs. placebo
✓ Show meaningful improvements as early as 4 weeks

Why This Study Matters

Daily supplementation with 400 mg of MucoSave™ FG for eight weeks significantly improved digestive comfort and gastrointestinal quality-of-life scores in healthy adults experiencing gastrointestinal discomfort, with improvements observed as early as four weeks. The findings suggest that MucoSave™ FG supports upper digestive tract comfort and healthy gastrointestinal function.*

Reference Link: https://clinicaltrials.gov/study/NCT04119817

Big-Picture Integration with Other Studies

  • Study 1: In a randomized placebo-controlled study of 118 adults with frequent upper digestive discomfort, a MucoSave™ FG-containing formulation taken daily for 8 weeks significantly improved digestive comfort (59.1% symptom reduction) and quality-of-life scores (56.5% improvement) compared with placebo.
  • Study 2: In a randomized placebo-controlled clinical study of 100 adults with gastrointestinal discomfort, 400 mg of MucoSave™ FG daily for 8 weeks significantly improved digestive comfort and gastrointestinal quality-of-life scores compared with placebo, with large reductions in heartburn, bloating, nausea, and throat irritation observed as early as 4 weeks.

MucoSave™ FG Ingredient Summary & Real-World Relevance

Two randomized, double-blind, placebo-controlled human clinical trials have evaluated the effects of MucoSave™ FG on digestive comfort and quality-of-life measures related to gastrointestinal well-being. In one eight-week study involving 118 adults experiencing frequent upper digestive discomfort, a formulation containing MucoSave™ FG significantly improved digestive symptom scores by 59.1% and digestive quality-of-life scores by 56.5% compared with placebo. A second clinical study involving 100 adults found that 400 mg of MucoSave™ FG daily for eight weeks significantly improved digestive comfort and gastrointestinal quality-of-life scores, with benefits observed as early as four weeks. Participants experienced meaningful reductions in symptoms such as bloating, gas, nausea, throat irritation, and post-meal digestive discomfort.

Together, these studies suggest that MucoSave™ FG supports the natural protective barrier of the upper digestive tract and promotes digestive comfort in individuals experiencing occasional digestive irritation. In practical terms, this may translate to improved comfort after meals, fewer episodes of upper digestive discomfort, reduced bloating and gas, and improved overall digestive well-being, making it a valuable ingredient for supporting healthy digestive function in everyday life.*

Ingredient Manufacturer Link: https://bionap.com/products/mucosave-fg

MucoSave™ FG is a clinically studied ingredient used in the following Silver Fern™ Brand products:

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.