Immune+ Protocol

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Immune imbalance can manifest as allergies, eczema, atopic and inflammation problems. If you have an imbalanced immune system, then you are likely uncomfortable. The opposite of immune imbalance is immune tolerance. Building a resilient and balanced immune system is essential for healthy inflammatory responses and effective immune responses. The keys to this is decreasing the pathogen load, restoring microbial balance, and improving gut barrier integrity. Silver Fern Brand’s Immune+ protocol is designed to help you do all of this and more!*

A Little Silver Fern™ History

One of our founders has Hashimoto’s. Like many of you, she needed help developing immune tolerance. She is now back to her radiant self, her brain fog and joint pains are gone, her hair grows again, and she even eats gluten again!

Another of our founders had bad allergies, both food and seasonal environmental that use to require weekly allergy shots. Through this Immune+ protocol process, he has developed a normal immune response to sicknesses without the severe problems he had in the past. His food allergies are gone, and his seasonal allergies have also substantially improved.

What’s the Answer?

Extinguish System Chaos!

Silver Fern™ has developed a targeted method to help promote immune tolerance, healthy immune responses, and healthy inflammatory responses in the gut barrier.*

Immune+ Protocol

Steps 1 & 2 Immune+ Protocol

Step 1 & 2 is designed to soak up the bad and help rebuild the good. Cleaning up the gut is foundational to rebalancing the immune system. To reduce pathogen load, you need to soak it all up: candida, bad bacteria, heavy metals, and other bad organisms. *

The Protocol may help with:

  • Gut barrier integrity*
  • Healthy inflammatory responses*
  • Immune tolerance and immune responses*
  • Diarrhea and loose stools*
  • Joint and muscle discomfort*
  • Muscle weakness*
  • Brain fog*
  • Bloating, nausea, reflux, and food problems*
  • Mucus in stool*
  • Dizziness, fatigue, and headaches*

Step 3 - Build Up Protocol

Step 3 is designed to help restore the good. When we help build up the gut, we go way beyond adding a dozen or so Lactobacillus and Bifidobacterium species. We focus on building up a wide diversity of key bacteria (including but not limited to the many possible strains of Lactobacillus and Bifidobacterium) like Akkermansia, Christensenella, and F. prausnitzii to promote the production of short-chain fatty acids and other key gut metabolites.*

This step may help with:

  • Gut microbial balance*
  • Gut barrier integrity*
  • Healthy inflammatory responses*
  • Immune tolerance and immune responses*
  • Skin problems*
  • Improving metabolic function*
  • Healthy cholesterol management*
  • Insulin sensitivity*

Step 1 Immune+ Protocol (60 Days)

First 60 days

Cleanse - 2 bottles per month

  • 4 capsules in the morning and 4 capsules in the evening with or without food

Reflux - 1 bottles per month

  • 1 scoop per day with or without a meal

Step 2 Immune+ Protocol (60 Days)

Next 60 days 

Cleanse - 4 bottles per month

  • 8 capsules in the morning and 8 capsules in the evening with or without food

Reflux - 2 bottles per month

  • 2 scoops per day with or without a meal

Step 3 Build Up Protocol (120 Days)

Last 120 days 

Ultimate Probiotic - 1 bottle per month

  • Week 1: 1 capsule per day
  • Week 2+: 2 capsules per day

Targeted Prebiotic - 1 bottle per month

  • 3 capsules per day, taken with Ultimate Probiotic

Sensitive Gut Fiber - 1 bottle per month

  • 1 scoop per day, taken with Ultimate Probiotic and Targeted Prebiotic

What Causes Immune Intolerance?

Dysfunctional regulatory T cells (Tregs) and dendritic cells (DCs) can lead to immune intolerance. Yes, genes can play into this, but not everyone with the genes for overreactive immune problems end up with them. Why? Your genes alone are not generally sufficient to induce the overreactive immune response. Gut imbalances, environment, and genes together can cause imbalances with Tregs and DCs that lead to immune intolerance problems.

What Causes Unhealthy Inflammatory Responses?

Genetics, toxins, gut mucosal damage and microbial imbalances are factors that contribute to dysfunctional inflammatory response. While we can’t change your genetics, we can help you reduce the body’s toxic load and repair gut disturbances.*

What Causes Unhealthy Allergic Responses?

Similar to inflammatory reactions, allergies are also caused by an overreactive immune system. When your immune system is overreactive it creates an excessive response to foreign proteins (allergens). This is an immune system imbalance. Approximately 80% of the immune system is located in the gut. When the gut is unhealthy, so is the immune system.

6 Things to Know About the Immune+ Protocol

  1. If you have any constipation, reflux, or slow motility issues, please start with the Slow Motility + protocol (Step 1) before starting the Immune+ Protocol. Slow motility issues can cause diarrhea, loose stools, and pathogen overgrowth. It is important to address this concern first as a clogged system will be very difficult to clean up!*
  2. For concerns with H. pylori overgrowth and other stomach imbalances, please open the capsules of Cleanse and pour the powder into water, juice, or food to consume. This will allow the immunoglobulins in Cleanse to help clean the stomach along with the intestines. *
  3. Cleanse contains antibodies or immunoglobulins that can act as binders. When a person has a high pathogen load and the immunoglobulins soak up a lot of pathogens or toxins, it may cause discomfort such as constipation, bloating, nausea, headaches, increased urination, or stomach cramps. If this happens, reduce the dosing by 50% for two weeks then slowly increase back to the normal dose. Be sure to drink more water and be more active. This is a sign the product is working, but you also need to adjust the protocols according to your body and needs. The discomforts should pass as things start to get cleaned up. *
  4. If you are concerned about stevia, monk fruit, or natural flavors, you may replace Reflux in this protocol with Regularity. Regularity contains the same key MucoSave® ingredient as Reflux. Replace 1 scoop of Reflux with 1 capsule of Regularity. You must open the capsules of Regularity to add to a food or drink of your choice for it to be effective in the stomach. It is critical for MucoSave® to be able to coat the esophagus and stomach. Opening the capsule and pouring it into a liquid is the preferred delivery method as this will maximize the contact area with the stomach lining. *
  5. MucoSave® in Reflux provides a rapid gel-like coating to the digestive system. This immediate change in the microbiome may cause some cause gas and bloating. If this occurs, reduce the dosing of Reflux for a week, then build back to the normal doses as your system allows. *

Reflux is a critical part of this protocol even if you don’t have Reflux, Heartburn, or indigestion issues. Reflux contains MucoSave® which is key to helping the mucosal barrier of the gut. The mucosal barrier of the gut is a key regulatory barrier between the immune system and the outside world. It can help control the immune response to determine the balance between tolerance and immune activation. Many studies see mucosal barrier integrity as one of the keys to immune tolerance. *


Cleanse contains a potent concentration of immunoglobulins (antibodies). These immunoglobulins do not enter the bloodstream, all their work is done in the gut! Cleanse is similar to colostrum but better! We selected ImmunoLin® with albumin for Cleanse. This is proven more potent than colostrum and is dairy-free. *

Cleanse may help:

  • Soak up bad bacteria, candida, mold, heavy metals, and other bad organisms in the gut*
  • Strengthen gut barrier function*
  • Improve nutrient absorption*
  • Heavy metal detoxification*
  • Promote immune tolerance and healthy immune response*
  • Promote healthy inflammatory responses*
  • Diarrhea and loose stools*
  • Bloating and gas*


Reflux is much more than its name suggests. The MucoSave® in Reflux is one of our “secret” ingredients for stomach and gut barrier health.*

Reflux may help:

  • Build stomach and intestinal barriers*
  • Improve nutrient absorption*
  • Bowel function and hydration*
  • Stomach issues*

This rare combination of products coats the system in a way that acts like sticky glue for grabbing nutrients and as an extinguisher to digestive barrier problems.*

Reflux - Mucosal Support *Mixed Berry or Peach Mango Flavor Options

The MucoSave™ ingredient found in Reflux-Mucosal Support attracts water to create a gentle gel-like texture that can help soothe, calm, and support the mucus layer to protect against foreign substances.*

Here are some of the many benefits of Reflux - Mucosal Support:*

  • Helps with reflux and heartburn*
  • Helps with nausea*
  • Helps with burping and belching*
  • Helps with mucus layer integrity*
  • Helps soothe the digestive system*
  • Helps with normal bowel function*

Dosing: Please take 1 scoop of Reflux after dinner. If you have a sensitive stomach, please consider taking only half a scoop of Reflux for the first week. Yes, you can take Reflux at other times of the day or mixed with your favorite drink.

Cleanse Daily Gut Detox

Contains ImmunoLin® - a concentration of beneficial immunoglobulins (IgG, IgM, IgA) or antibodies. These antibodies stay within your digestive tract (they do not enter your bloodstream) and help to bind and neutralize harmful substances before they can reach circulation and cause problems*

Here are some of the many benefits of Cleanse:*

  • Helps with diarrhea and loose stools*
  • Promotes microbial balance*
  • Helps with normal digestion and nutrient absorption*
  • Helps with normal immune responses*
  • Promotes a strong gut barrier*
  • Promotes normal inflammatory responses*

Dosing: Start with taking 2 capsules in the morning and 2 capsules in the evening for the first week After the first week move to taking 4 capsules in the morning and 4 capsules in the evening with or without food. Cleanse acts as a binder, not a laxative.

Ultimate Probiotic

Silver Fern™ Brand’s Ultimate Probiotic was formulated by a microbiologist who pioneered an entirely new category of probiotics:  spore-based probiotics! This was a break from the trend of traditional Lactobacillus and Bifidobacteria species, which can die off in the stomach before reaching the colon. The Bacillus strains used in Ultimate Probiotic have a spore coating that protects the probiotic from harsh stomach acids and other digestive conditions. Plus, we added a probiotic yeast, which may fight against harmful yeasts in the gut. We call Ultimate Probiotic the "gut gardener" because it helps manage the environment of the microbiome in the gut like a gardener would.*

Ultimate Probiotic may help:

  • Increase diversity of beneficial bacteria*
  • Push out harmful bacteria*
  • Strengthen the gut barrier *
  • Increase digestive enzyme production to help with food intolerances*
  • Improve heavy metal detoxification*

Targeted Prebiotic (XOS, citrus bioflavonoids, apple extract)

The purpose of Targeted Prebiotic is to feed species in the gut that cannot be taken directly as a supplement. This product can rapidly reshape the composition of the gut microbiome. Most prebiotic fibers feed all the bacteria in the gut, good and bad. Targeted Prebiotic, however, selectively feeds the most important microbial populations.* 

Targeted Prebiotic may help:

  • Increase multiple beneficial bacteria species such as Bifidobacterium, F. prausnitzii, Akkermansia* Clostridium Cluster XIVa*
  • Increase short-chain fatty acids, especially butyrate*
  • Balance the microbiome and reduce pathogen load*
  • Improve gut barrier integrity*
  • Restore normal inflammatory responses*

Sensitive Gut Fiber (galactomannan, baobab acacia)

While Sensitive Gut Fiber was designed to help with constipation and diarrhea issues, it turned out to be much more than that. * This low FODMAP prebiotic supplement can also help:

  • Increase Bifidobacterium, Lactobacillus, and F. prausnitzii species*
  • Increase Akkermansia, Christensella, Prevotella, Lachnospira and Ruminococca species*
  • Increase short-chain fatty acids, especially butyrate*
  • Improve gut barrier integrity*
  • Support bowel regularity*
  • Restore normal inflammatory responses*

* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.