RiaGev® - Clinical Research Data Summary

RiaGev® Nicotinamide & D-Ribose Cellular Energy Complex

RiaGev® is a clinically studied ingredient used in the following Silver Fern™ Brand products:

Introduction

RiaGev® is formulated with ingredients that play a role in cellular energy metabolism. Energy production begins within the mitochondria, where nutrients are involved in the generation of ATP, the body's primary energy molecule. The following studies highlight research related to key ingredients used in RiaGev®, including their roles in supporting ATP production, mitochondrial function, and normal energy metabolism. This research helps illustrate how nutritional compounds involved in cellular energy pathways may support overall energy, physical performance, and general wellness.*

These are the studies for RiaGev®. Below, we provided a summary of each key data for each study, along with a link to the complete clinical research.

  1. Summary of Study 1 – Full Study: https://pubmed.ncbi.nlm.nih.gov/17109576/
  2. Summary of Study 2 – Full Study: https://pubmed.ncbi.nlm.nih.gov/35684021/

Ingredient Manufacturer Link: https://bioenergylifescience.com/riagev/



Study 1 Summary

Complete Study Information: https://pubmed.ncbi.nlm.nih.gov/17109576/

The Use of D-Ribose in Individuals with Low Cellular Energy: Pilot Study
J Altern Complement Med. 2006 Nov;12(9):857-62.

This open-label pilot study evaluated the effects of D-ribose supplementation in 41 adults diagnosed with chronic fatigue syndrome and/or fibromyalgia over 5 weeks, assessing self-reported measures related to energy, sleep quality, mental clarity, comfort, and overall well-being.

Study Design Highlights

  • Study type: Open-label pilot study
  • Participants: 41 adults diagnosed with chronic fatigue syndrome and/or fibromyalgia
  • Dose: 5 g D-ribose three times daily (15 g/day total)
  • Duration: 5 weeks
  • Outcomes: Self-reported energy, sleep quality, mental clarity, comfort, overall well-being

Key Findings (What the Study Showed)

  • Participants reported improvements from baseline in energy levels, overall well-being, sleep quality, mental clarity, and comfort during the study period
  • Approximately two-thirds of participants reported improvement in one or more of the measured wellness categories
  • D-ribose supplementation was generally well tolerated with no serious adverse events reported
  • The authors noted that additional controlled studies are needed to further evaluate these findings

Benefits of RiaGev® Supported by This Study

Based on the pilot study findings, D-ribose supplementation was associated with:
✓ Self-reported improvements in energy levels in approximately two-thirds of participants
✓ Self-reported improvements in sleep quality, mental clarity, and comfort
✓ Self-reported improvements in overall well-being during the supplementation period
✓ Good tolerability with no serious adverse events

Why This Study Matters

Because D-ribose is a structural component used by the body to produce ATP, these findings help illustrate its role in supporting normal cellular energy production. Nutritional compounds involved in ATP synthesis may help support overall energy, mental clarity, and physical performance, particularly in individuals experiencing increased energy demands or reduced cellular energy availability. As a pilot study, these findings are preliminary and inform the basis for further controlled research.*

Reference Link: https://pubmed.ncbi.nlm.nih.gov/17109576/



Study 2 Summary

Complete Study Information: https://pubmed.ncbi.nlm.nih.gov/35684021/

A Combination of Nicotinamide and D-Ribose (RiaGev®) and Its Effects on NAD⁺ Levels in Healthy Middle-Aged Adults
Nutrients. 2022 May 26;14(11):2219. doi: 10.3390/nu14112219.

This randomized, triple-blind, placebo-controlled, crossover pilot clinical trial evaluated the effects and safety of RiaGev® (nicotinamide + D-ribose) on NAD⁺ metabolome levels in 50 healthy middle-aged adults (ages 36–65). The crossover design allowed each participant to serve as their own control, with both RiaGev® and placebo phases separated by a washout period.

Study Design Highlights

  • Study design: Randomized, triple-blind, placebo-controlled, crossover pilot clinical trial
  • Participants: 50 healthy adults (ages 36–65)
  • Dose: 1,520 mg RiaGev® twice daily (3,040 mg/day total)
  • Duration: 7 days per intervention phase
  • Design: Crossover (each participant received both RiaGev® and placebo)
  • Primary outcomes: NAD⁺ metabolome levels (NAD⁺, NADH, NADP⁺, NADPH)

Key Findings (What the Study Showed)

1. Changes in NAD⁺-Related Metabolites

After 7 days of supplementation, researchers reported increases in several NAD⁺-related metabolites compared with placebo:

  • NADP⁺: ~27% increase (statistically significant)
  • Increases observed across NAD⁺, NADH, NADP⁺, and NADPH
  • These molecules play roles in cellular energy metabolism and redox processes within the body

2. Observations in Additional Biomarkers

Researchers also reported changes in several measured biomarkers compared with placebo, including markers related to glucose metabolism and oxidative stress.

3. Safety and Tolerability

  • No adverse events reported
  • Clinical safety measures (hematology, liver enzymes, kidney markers, vital signs) remained within normal reference ranges throughout the study
  • RiaGev® was reported to be well tolerated

Benefits of RiaGev® Demonstrated by This Study

Based directly on the clinical outcomes, RiaGev® at 3,040 mg/day for 7 days was shown to:
✓ Support a statistically significant ~27% increase in NADP⁺ vs. placebo
✓ Support increases across the NAD⁺ metabolome including NAD⁺, NADH, and NADPH
✓ Influence markers related to glucose metabolism and oxidative stress
✓ Demonstrate changes in cellular energy metabolites within a 7-day supplementation period
✓ Be well tolerated with no adverse events and normal clinical safety markers

Why This Study Matters

In this randomized, triple-blind, placebo-controlled crossover study, supplementation with RiaGev® was associated with increases in several NAD⁺-related metabolites in healthy adults. Because NAD⁺ and related compounds play central roles in cellular energy metabolism and redox balance, these findings help illustrate how supporting NAD⁺ metabolism may influence foundational cellular processes involved in energy production and antioxidant defense. The 7-day timeframe suggests that nutritional compounds involved in NAD⁺ metabolism may influence cellular metabolic pathways over relatively short supplementation periods, though additional research continues to explore these findings.*

Reference Link: https://pubmed.ncbi.nlm.nih.gov/35684021/

Big-Picture Integration with Other Studies

  • Study 1: In a 5-week pilot study, 15 g/day of D-ribose was evaluated in adults with reduced cellular energy. Approximately two-thirds of participants reported improvements from baseline in energy levels, sleep quality, mental clarity, comfort, and overall well-being. As a pilot study, these findings are preliminary and inform the basis for further controlled research.
  • Study 2: In a randomized, triple-blind, placebo-controlled crossover trial, 7 days of RiaGev® supplementation (3,040 mg/day) was associated with increases in several NAD⁺-related metabolites in healthy middle-aged adults, including an approximately 27% statistically significant increase in NADP⁺ compared with placebo, alongside changes in markers related to glucose metabolism and oxidative stress. RiaGev® was well tolerated with no adverse events.

RiaGev® Ingredient Summary & Real-World Relevance

RiaGev® contains ingredients that participate in cellular energy metabolism. D-ribose is a naturally occurring carbohydrate that serves as a structural component used in the formation of adenosine triphosphate (ATP), the body's primary energy molecule. When combined with nicotinamide, a precursor involved in NAD⁺ metabolism, these ingredients help support metabolic pathways related to cellular energy production and redox balance. NAD⁺ and related metabolites play important roles in mitochondrial function, cellular metabolism, and normal energy production.*

The research summarized above provides scientific context for how nutritional compounds involved in ATP and NAD⁺ metabolism may help support cellular energy processes and overall metabolic function. Together, these findings illustrate how supporting the body's foundational energy pathways through nutritional ingredients may contribute to overall energy, physical performance, and general wellness.*

Ingredient Manufacturer Link: https://bioenergylifescience.com/riagev/

RiaGev® is a clinically studied ingredient used in the following Silver Fern™ Brand products:

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Go to full site