aXivite® - Clinical Research Data Summary

aXivite® Microencapsulated Phenylcapsaicin

aXivite® is a clinically studied ingredient used in the following Silver Fern™ Brand product:

Metabolism – https://www.silverfernbrand.com/products/metabolism

Introduction

aXivite® is a patented, microencapsulated form of phenylcapsaicin designed to provide the metabolic and performance-related properties associated with capsaicin without the pungency or gastrointestinal discomfort often experienced with traditional chili pepper extracts. Human clinical research has evaluated aXivite® for its potential role in supporting metabolic activity, exercise capacity, and post-exercise recovery at low, well-tolerated doses. In acute exercise studies, phenylcapsaicin supplementation was associated with increased fat oxidation, improved aerobic efficiency, and reduced perceived exertion during exercise. Additional research in resistance-trained individuals reported changes in squat performance measurements along with reductions in perceived muscle fatigue and markers of exercise-related muscle stress. Longer-term supplementation has also been studied for its potential role in supporting intestinal barrier function, as measured by serum zonulin, with associated changes in body composition observed in healthy adults.*

These are the studies for aXivite®. Below we provide a summary of the key findings from each study, along with links to the complete clinical research. The following summaries describe results observed in specific clinical studies of phenylcapsaicin and are provided for educational purposes. Individual results may vary, and the studies evaluated the ingredient itself rather than the finished product.

Ingredient Manufacturer Link: https://axivite.com/

Study 1 Summary

Complete Study Information: https://pubmed.ncbi.nlm.nih.gov/37228817/

Effects of Phenylcapsaicin on Aerobic Capacity and Physiological Parameters in Active Young Males
Frontiers in Physiology. 2023;14:1190345.

This randomized, triple-blinded, placebo-controlled, crossover trial evaluated the acute effects of phenylcapsaicin on aerobic performance and physiological responses during exercise in physically active young males. Participants completed multiple exercise testing sessions after ingesting either a low dose of phenylcapsaicin, a high dose of phenylcapsaicin, or a placebo prior to exercise. Researchers assessed maximal fat oxidation, oxygen consumption, heart rate, lactate levels, thermoregulation, and ratings of perceived exertion during aerobic exercise challenges. Compared with placebo, phenylcapsaicin supplementation was associated with increases in fat oxidation during exercise and reductions in perceived exertion, along with changes in several physiological markers related to exercise performance.

Study Design Highlights

Study design: Randomized, triple-blinded, placebo-controlled, crossover trial
Population: Physically active young males
Intervention: Single oral dose taken 45 minutes prior to exercise
Doses evaluated:
- Low dose: 0.625 mg phenylcapsaicin
- High dose: 2.5 mg phenylcapsaicin
- Placebo
Exercise protocol: Aerobic exercise testing designed to assess metabolic and physiological responses during exercise

Key Findings (What the Study Showed)

1. Maximal Fat Oxidation

Both low and high doses of phenylcapsaicin were associated with increased maximal fat oxidation during exercise compared with placebo, indicating a shift toward greater fat utilization during physical activity.

2. Perceived Exertion

Participants reported lower ratings of perceived exertion during exercise following phenylcapsaicin supplementation compared with placebo.

3. Heart Rate Response

The higher phenylcapsaicin dose was associated with lower maximal heart rate during exercise testing compared with placebo.

4. Thermoregulation

Participants reported lower perceived body temperature during exercise sessions with phenylcapsaicin supplementation.

5. Lactate Response

Changes in lactate response during exercise testing suggested potential differences in metabolic stress during exercise following phenylcapsaicin intake.

Benefits of aXivite® Demonstrated by This Study

Based directly on the clinical outcomes, aXivite® (phenylcapsaicin) was shown to:
✓ Support increased maximal fat oxidation during aerobic exercise
✓ Help reduce ratings of perceived exertion during exercise
✓ Support lower maximal heart rate during exercise at the higher dose
✓ Support lower perceived body temperature during physical activity
✓ Influence lactate-related markers associated with metabolic stress during exercise

Why This Study Matters

These findings suggest phenylcapsaicin may support several aspects of exercise performance, including metabolic activity during physical activity and perceived effort during training. For individuals engaging in aerobic exercise, ingredients such as phenylcapsaicin may help support efficient energy utilization and exercise comfort without relying on stimulant-based compounds. In this study, phenylcapsaicin was consumed 45 minutes prior to exercise, and physiological responses were evaluated during the same exercise session.*

Reference Link: https://pubmed.ncbi.nlm.nih.gov/37228817/

Study 2 Summary

Complete Study Information: https://pubmed.ncbi.nlm.nih.gov/37086038/

Effects of Different Phenylcapsaicin Doses on Resistance Training Performance, Muscle Damage, and Recovery
Journal of the International Society of Sports Nutrition. 2023;20(1):2204083.

This randomized, triple-blinded, placebo-controlled crossover trial evaluated the effects of phenylcapsaicin supplementation on resistance exercise performance and physiological responses in 25 resistance-trained young men. Participants completed standardized squat-based resistance training sessions after ingesting either a low dose (0.625 mg), a high dose (2.5 mg) of phenylcapsaicin, or placebo prior to exercise. Researchers assessed lifting velocity, ratings of perceived exertion, biochemical markers associated with muscle stress, metabolic responses, and recovery measurements up to 24 hours following exercise.

Study Design Highlights

Study design: Randomized, triple-blinded, placebo-controlled crossover trial
Population: 25 resistance-trained young men
Intervention: Single oral dose taken prior to resistance exercise
Doses evaluated:
- Low dose: 0.625 mg phenylcapsaicin
- High dose: 2.5 mg phenylcapsaicin
- Placebo
Exercise protocol: Standardized squat-based resistance training followed by recovery assessments up to 24 hours post-exercise

Key Findings (What the Study Showed)

1. Squat Performance

The high-dose phenylcapsaicin condition was associated with faster squat lifting velocities compared with the low-dose and placebo conditions during the resistance exercise protocol.

2. Perceived Exertion

Participants reported lower ratings of perceived exertion in the active muscle group following high-dose phenylcapsaicin supplementation compared with placebo.

3. Markers Associated with Muscle Stress

Biochemical markers associated with exercise-related muscle stress measured 24 hours after exercise were lower in the high-dose phenylcapsaicin condition compared with placebo.

4. Metabolic Markers

No adverse changes were observed in metabolic markers or protein breakdown indicators during the study.

Benefits of aXivite® Demonstrated by This Study

Based directly on the clinical outcomes, aXivite® (phenylcapsaicin) was shown to:
✓ Support faster squat lifting velocities during resistance training
✓ Help reduce perceived exertion in active muscle groups during exercise
✓ Support lower markers of exercise-related muscle stress 24 hours post-exercise
✓ Demonstrate no adverse changes in metabolic markers or protein breakdown indicators
✓ Provide performance and recovery support without relying on stimulant compounds

Why This Study Matters

These findings suggest phenylcapsaicin may support aspects of exercise performance and post-exercise recovery when taken prior to resistance training. Ingredients such as phenylcapsaicin may help support normal exercise tolerance and training comfort without relying on stimulant compounds. In this study, phenylcapsaicin was consumed prior to resistance training, and outcomes were assessed during exercise and up to 24 hours after the training session.*

Reference Link: https://pubmed.ncbi.nlm.nih.gov/37086038/

Study 3 Summary

Complete Study Information: https://www.ijocs.org/clinical-journal/placebo-controlled-study-to-investigate-the-relationship-between-lowering-serum-zonulin-levels-and-improved-body-weight-compositio-15597.html

Body Composition Following Phenylcapsaicin Supplementation
International Journal of Clinical Studies. 2022.

This randomized, double-blind, parallel-group human clinical trial evaluated the effects of daily phenylcapsaicin supplementation on serum zonulin levels and body composition measurements in healthy adults. Participants received either a low dose of phenylcapsaicin, a higher dose of phenylcapsaicin, or placebo for 54 days, alongside standardized diet and lifestyle guidance. Researchers used serum zonulin as a biomarker associated with intestinal barrier function and evaluated changes in body composition during the study period.

Study Design Highlights

Study design: Randomized, double-blind, parallel-group clinical trial
Population: Healthy adult men and women
Duration: 54 days
Doses evaluated:
- Low dose: 0.560 mg phenylcapsaicin per day
- Higher dose: phenylcapsaicin (study comparator)
- Placebo
Primary biomarker: Serum zonulin, a marker associated with intestinal permeability

Key Findings (What the Study Showed)

1. Serum Zonulin

Participants receiving the low dose of phenylcapsaicin experienced reductions in serum zonulin levels during the study period compared with baseline measurements.

2. Body Composition

Changes in body composition measurements were observed in the low-dose phenylcapsaicin group and were associated with reductions in serum zonulin levels.

3. Dose Response

The observed changes were more pronounced in the low-dose phenylcapsaicin group compared with the higher-dose group.

Benefits of aXivite® Demonstrated by This Study

Based directly on the clinical outcomes, aXivite® (phenylcapsaicin) was shown to:
✓ Support reductions in serum zonulin, a biomarker associated with intestinal barrier function
✓ Support changes in body composition measurements over 54 days
✓ Demonstrate meaningful effects at a low daily dose of 0.560 mg
✓ Show an association between intestinal barrier markers and body composition changes

Why This Study Matters

These findings suggest phenylcapsaicin may support aspects of digestive health and metabolic balance through its potential influence on intestinal barrier-related biomarkers. Supporting intestinal barrier function may play a role in overall metabolic and digestive wellness. Participants consumed phenylcapsaicin daily for 54 days during the study period, providing longer-term context for the ingredient's effects beyond acute exercise applications.*

Reference Link: https://www.ijocs.org/clinical-journal/placebo-controlled-study-to-investigate-the-relationship-between-lowering-serum-zonulin-levels-and-improved-body-weight-compositio-15597.html

Big-Picture Integration with Other Studies

Study 1: A randomized, triple-blinded, placebo-controlled crossover trial evaluated the effects of a single dose of phenylcapsaicin taken 45 minutes before exercise and reported increases in fat oxidation, reduced perceived exertion, and improvements in aerobic efficiency in physically active young males compared with placebo.
Study 2: A randomized, triple-blinded, placebo-controlled crossover trial reported that a single 2.5 mg dose of phenylcapsaicin taken before resistance training was associated with improvements in squat performance, reduced perceived muscle fatigue, and lower markers of muscle damage up to 24 hours after exercise in resistance-trained men.
Study 3: A randomized, double-blind, parallel-group human trial found that 54 days of low-dose phenylcapsaicin supplementation (0.560 mg/day) reduced serum zonulin levels and was associated with changes in body composition compared with placebo in healthy adults.

aXivite® Ingredient Summary & Real-World Relevance

aXivite® is a clinically studied, non-stimulant phenylcapsaicin that has been evaluated for its potential to support metabolic activity, exercise performance, and recovery at low doses. Human studies suggest phenylcapsaicin supplementation may help support fat oxidation during exercise, reduce perceived effort during training, and support normal muscle recovery following intense physical activity. Additional research indicates phenylcapsaicin may also support intestinal barrier function, which plays an important role in overall metabolic and digestive health.*

Ingredient Manufacturer Link: https://axivite.com/

aXivite® is a clinically studied ingredient used in the following Silver Fern™ Brand product:

Metabolism

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.