Altilix™ - Clinical Research Data Summary

ALTILIX™ Artichoke Leaf Extract

ALTILIX™ is a clinically studied ingredient used in the following Silver Fern™ Brand product:

Introduction

ALTILIX™ is a clinically studied artichoke leaf extract standardized to chlorogenic acid and luteolin derivatives that help support healthy liver function, metabolic balance, and cardiovascular health.

In a 6-month randomized, double-blind, placebo-controlled clinical study (150 mg/day in 100 adults with metabolic risk factors), supplementation with ALTILIX™ was associated with improvements in markers related to glucose metabolism, lipid balance, liver enzyme levels, and vascular function. The study also observed changes in measurements related to insulin sensitivity, cholesterol and triglyceride levels, fatty liver index, endothelial function, and carotid intima-media thickness.

These are the studies for ALTILIX™. Below, we provided a summary of each key data for each study, along with a link to the complete clinical research.

  1. Summary of Study 1 – Full Study: https://www.mdpi.com/2072-6643/11/11/2580

Ingredient Manufacturer Link: https://bionap.com/products/altilix



Study 1 Summary

Complete Study Information: https://www.mdpi.com/2072-6643/11/11/2580

Castellino et al., Nutrients (2019)

ALTILIX™ has been evaluated in human clinical research examining markers related to metabolic health, liver enzyme balance, lipid metabolism, and vascular function. ALTILIX™ is a Sicilian artichoke leaf extract standardized to chlorogenic acid and luteolin derivatives and produced through a traceable and ethically sourced supply chain.

Key bioactive compounds include:

  • Chlorogenic acid & derivatives:
    • Support healthy liver function
    • Support normal bile production and digestive processes
  • Flavonoids (luteolin-7-glucoside):
    • Help support healthy lipid metabolism
    • Provide antioxidant support that helps protect lipids from oxidative stress

Study Design Highlights

  • Study design: Randomized, double-blind, placebo-controlled
  • Duration: 6 months
  • Participants: 100 adults with metabolic risk factors
  • Dose: 150 mg/day ALTILIX™

Key Findings (What the Study Showed)

1. Liver-Related Markers

Supplementation with ALTILIX™ was associated with improvements in markers related to liver health, including:

  • Changes in fatty liver index (FLI)
  • Reductions in liver enzyme markers ALT and AST
  • Improvements in the AST/ALT ratio

2. Glucose Metabolism Markers

The study observed improvements in markers related to glucose metabolism and insulin sensitivity, including:

  • HbA1c
  • HOMA-IR (insulin resistance marker)
  • HOMA-β (beta-cell function marker)

3. Lipid Profile Markers

ALTILIX™ supplementation was associated with improvements in lipid markers including:

  • Total cholesterol
  • Triglycerides
  • LDL cholesterol

4. Cardiovascular Markers

Researchers also observed improvements in markers related to vascular health:

  • Carotid intima-media thickness (cIMT)
  • Flow-mediated dilation (FMD)

Supporting Laboratory Research

Laboratory research using cultured liver cells exposed to high levels of fatty acids found that ALTILIX™ reduced lipid accumulation in hepatocytes compared to untreated controls. In this model, ALTILIX™ showed activity comparable to silibinin (a compound derived from milk thistle) used as a reference compound. Gene expression analysis suggested the extract may influence pathways involved in fat metabolism in liver cells, including markers related to lipid synthesis and storage.

Benefits of ALTILIX™ Demonstrated by This Study

Based directly on the clinical outcomes, ALTILIX™ was shown to:
✓ Support healthy glucose and lipid metabolism
✓ Help maintain healthy cholesterol and triglyceride levels already within the normal range
✓ Support liver health and normal liver enzyme balance
✓ Support healthy body composition and waist circumference
✓ Support vascular and cardiovascular function

Why This Study Matters

This study provides human clinical evidence that ALTILIX™ functions as a systems-level metabolic support ingredient, not merely a single-pathway liver supplement. Over 6 months, ALTILIX™ was associated with improvements across liver enzyme balance, glucose and insulin markers, lipid metabolism, and vascular health—all within a well-designed, placebo-controlled trial. Supporting laboratory research further illustrates how artichoke-derived compounds may influence lipid metabolism at the cellular level, with activity comparable to established reference compounds. Together, these findings position ALTILIX™ as a clinically relevant ingredient for comprehensive metabolic and liver health support.*

Reference Link: https://www.mdpi.com/2072-6643/11/11/2580

Big-Picture Integration with Other Studies

  • Study 1: Associated with improvements in markers related to glucose metabolism, insulin sensitivity, liver enzyme balance, lipid profile, and vascular health in a 6-month randomized, double-blind, placebo-controlled clinical trial in adults with metabolic risk factors.

ALTILIX™ Ingredient Summary & Real-World Relevance

The liver plays a central role in regulating metabolism, cholesterol balance, blood sugar, and detoxification processes. Modern diets, stress, and metabolic strain can place additional demands on these systems.

ALTILIX™ provides clinically studied artichoke-derived compounds that help support healthy liver function, lipid metabolism, and glucose balance. By supporting key metabolic processes involved in energy regulation, vascular health, and liver enzyme balance, ALTILIX™ helps support metabolic resilience and long-term health.

Together, these clinically studied compounds help support healthy liver function, metabolic balance, and cardiovascular wellness—making ALTILIX™ a valuable component of comprehensive metabolic and liver support.*

Ingredient Manufacturer Link: https://bionap.com/products/altilix

ALTILIX™ is a clinically studied ingredient used in the following Silver Fern™ Brand product:

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

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